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However, like any medical treatment, it should be performed after proper consultation and evaluation

A drug can be metabolized in the gut wall (eg, by the CYP3A4 enzyme system) or even in the portal blood, but most commonly it is the liver that is responsible for metabolism before the drug reaches the systemic circulation

Typical progression: Week 12 Improved energy levels Week 34 Better endurance Week 6+ Gradual fat loss Studies indicate modest fat loss (~1 kg over time) when combined with exercise

MT-II activation at these receptors reduces food intake in animal models, and appetite suppression is a commonly reported effect in human use